Neurobiology of Disease Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer’s Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation
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چکیده
Dalia Halawani,1 Sylvain Tessier,2 Dominique Anzellotti,1 David A. Bennett,3 Martin Latterich,1,4 and Andréa C. LeBlanc5,6 1Department of Anatomy and Cell Biology, McGill University, Montréal, Québec H3T 1E2, Canada, 2Institut de Recherches Cliniques de Montréal, Université de Montréal, Montréal, Québec H2W 1R7, Canada, 3Rush University Medical Center, Chicago, Illinois 60612, 4Proteogenomics Research Institute for Systems Medicine, San Diego, California, 92121-1206, 5Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and 6Department of Neurology and Neurosurgery, McGill University, Montréal, Québec H3A 2B4, Canada
منابع مشابه
Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.
Cockayne syndrome group A and B (CSB) proteins act in transcription-coupled repair, a subpathway of nucleotide excision repair. Here we demonstrate that valosin-containing protein (VCP)/p97 segregase functions in ultraviolet radiation (UVR)-induced ubiquitin-mediated CSB degradation. We show that VCP/p97 inhibition and siRNA-mediated ablation of VCP/p97 and its cofactors UFD1 and UBXD7 impair C...
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RNA polymerase II (RNAPII) acts as a damage sensor for transcription-coupled nucleotide excision repair (TC-NER) and undergoes proteolytic clearance from damaged chromatin by the ubiquitin-proteasome system (UPS). Here, we report that Valosin-containing protein (VCP)/p97, a druggable oncotarget, is essential for RNAPII's proteolytic clearance in mammalian cells. We show that inhibition of VCP/p...
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تاریخ انتشار 2010